When people want to administer testosterone they often have this question in their mind – ‘What is the difference between testosterone Enanthate and Cypionate.’ People often assume that these two substances are so similar that the differences don’t matter. Well, that does matter. It will matter a lot when you are taking these options for treating the low T or testosterone deficiency as per doctor’s prescription. Let’s check out how the difference matters in testosterone replacement therapy (TRT).
Both of these compounds are pharmaceutically made forms of bio-similar male androgen. And these are administered for increasing the clinically insufficient levels of testosterone. Both of them can be categorized as slow-acting testosterone esters that release within 10 to 14 days. The Cypionate version is suspended in cottonseed oil. And it has an 8-carbon ester chain. On the other hand, Enanthate is suspended in sesame oil. And it has a 7-carbon ester chain (https://www.nexelmedical.com/testosterone-cypionate/what-is-the-difference-between-testosterone-cypionate-and-enanthate/).
These are considerably interchangeable for medical use. Some patients come with strong preferences regarding administering one form instead of the other. It is because of the little different features of each. Cypionate, that is likely to be the more common version that US doctors prescribe, comes with a longer active life. This is because of its slightly slower release time than Enanthate. That is why it needs fewer injections during the treatment cycle of a patient.
And this difference between Testosterone Cypionate and Enanthate treatments matter a lot for the users. For some patients, the most meaningful factor is the difference between their prices. However, these two prescription compounds don’t typically vary much when it comes to their usage costs. After knowing the preference of the patient the TRT doctor will prescribe the best suitable form of treatment.
Testosterone And Estradiol
Some people focused on the difference between testosterone Cypionate and Enanthate don’t often consider that there are other factors too that can make a difference regarding their male hormone supply. One of those crucial things is to learn about estrogen or estradiol, usually identified on blood tests as E2.
However, how it can impact the testosterone levels of the body? Estradiol strongly influences the male hormone levels. And there are several factors that can boost the level of estradiol the body produces. In a single sentence, having more estradiol means having lesser testosterone.
E2 binds to the androgen receptors in the body and causes them to become useless. And thus, it becomes a testosterone receptor antagonist. It also encourages the body to produce fewer androgen receptors with the passing time. And if it binds to estrogen receptors successfully, it gets them activated.
When you have higher estrogen levels in your body, you tend to develop excess belly fat. Also, this leads to gynecomastia, “man boobs”, and prostate enlargement, etc. However, opting for only TRT may not be sufficient to deal with the situation. It is because the supplemental testosterone it supplies requires androgen receptors to bind to. And the endocrine system may not have a sufficient amount of these elements.
All these might happen because of estradiol production that is promoted by the presence of the aromatase enzyme in the body. Considering the difference between Testosterone Enanthate and Cypionate will not matter much under these physiological circumstances.
However, aromatase inhibitors can bind to the aromatase enzymes in your body and prevent them from transforming the testosterone into estradiol. Therefore, some TRT patients might need to administer an AI (aromatase inhibitor) for effective treatment. Remember, you will need to discuss this with your physician prescribing the therapy.
It is because it can greatly impact the results whether you administer Testosterone Cypionate or Testosterone Enanthate. It is always a brilliant idea to make a list of all of the questions you may have regarding administering TRT before you consult a TRT doctor or visit a clinic for treating low T symptoms.
Answers To All Testosterone Therapy Questions
Maybe you have a realization that there could be other crucial aspects regarding using TRT that you may not know yet. Or maybe you will like to discuss the differences between Testosterone Cypionate and Enanthate with an expert. The more you will understand the various forms of TRT work – and what prevents them from functioning – the more effective your treatment will be.
Always stay updated with the latest and comprehensive information regarding hormone replacement therapy. The TRT programs are available to adults across the US, and you can easily get accurate and helpful information regarding Testosterone deficiency treatment options.
You can easily get this information, without any obligation. The experts are always ready to answer the questions on your list. So feel free to discuss everything you want to learn about administering any type of TRT. The experts will answer all your questions and personal concerns regarding a TRT.
Now, if you think that will the extensive knowledge make a difference in the therapy at all, the answer is yes. And make sure that you are consulting the experienced experts only. Only they can help you solve all the confusion and will let you learn the right dosage and the safety measures. Thus, you can enjoy a testosterone replacement therapy that is effective and safe as well.
However, before we further dig into this topic, let’s check out these compounds in detail.
What is Testosterone Cypionate?
Testosterone Cypionate is a generic pharmaceutical version of testosterone that is often administered for the treatment of testosterone deficiency in men. You can get this product in the market often in the brand names of Depo-Testosterone, Duratest, and Testoject LA.
When it comes to restoring a healthy testosterone level in the body, Testosterone Cypionate is a considerably advantageous form of hormone/testosterone replacement therapy (TRT). And this is well-tolerated by most of the patients. Just as any compound, Testosterone Cypionate comes with various advantages and side effects. And you should be aware of all those factors before using it.
Also, it is crucial to note that Testosterone Cypionate is a schedule-III controlled compound in the United States. That means the US citizens cannot legally administer it without a prescription. Also, here they need the guidance of a licensed and trained physician.
Later on, this guide will let you know everything you need to know about Testosterone Cypionate as well as Enanthate. You will learn the benefits, side effects, etc. (https://gamedaymenshealth.com/testosterone-cypionate-injection/).
Testosterone Cypionate is an ester of testosterone that is the primary male sex hormone or androgen naturally produced in the human body. In the chemical terms, esters are organic or carbon-based substances derived from acids where at least one -OH (hydroxyl) the substituent is exchanged by an -OR (alkoxy) substituent.
This conversion to the chemical structure of testosterone converts it into a “prodrug.” That means your body converts it into a biologically active form after taking it. Testosterone Cypionate is a manmade AAS or Androgenic-Anabolic steroid. Still, it is considered a natural hormone because the body metabolizes it and converts it into the bioidentical version of testosterone.
The intake of testosterone esters such as Testosterone Cypionate – is beneficial in clinical uses for various reasons:
- You can control the effective half-life and duration of action of testosterone
- It helps in improving the bioavailability of testosterone
- It is easy to manipulate the dosage
- The time between administrations increases noticeably
There are various other testosterone esters involved in medicine, for the treatment of low ‘T’, Those products are Testosterone Propionate, Testosterone Undecanoate, and Testosterone Enanthate. However, it is the most common ester that experts recommend in the USA for testosterone replacement therapy (TRT).
Testosterone Cypionate Side Effects
The most noticeable initial side-effect of Testosterone Cypionate injections is soreness at the injection site. For those who are new to TRT and injections, this is completely normal (and expected). Testosterone Cypionate is available in an oil base (depot) as a deep intramuscular injection, generally.
The benefit of this is that this compound disperses slowly over a long period and that is very bioavailable. The disadvantage is that it can leave the inject site stiff and sore. However, over a period, the muscles at the injection site will adapt. And the stiffness and soreness will lessen every time you take injections.
Other side-effects of administering Testosterone Cypionate in TRT are minimal. And those are easy to manage. Males may come across side effects such as oily skin, acne, night sweats, during the initial phase of using testosterone Cypionate. However, the side effects are cosmetic in most cases. And users can easily control these with over-the-counter skin ointments.
Long-term administering of testosterone Cypionate can cause several physiological side effect including blood pressure increase, increased cholesterol, etc. However, with regular basis bloodwork and dietary support, most male users can keep cardiovascular and metabolic biomarkers within the healthy range during administering Testosterone Cypionate.
What is Testosterone Enanthate?
Testosterone Enanthate is an ester derived from the naturally produced androgen, testosterone. It operates the normal growth and development of male sexual traits. People suffering from testosterone insufficiency can deal with the functional, anatomic, and psychic deficiency symptoms by substituting testosterone or going through TRT or Testosterone Replacement Therapy.
Testosterone Enanthate is one of the many testosterone substances. In the male, it is usually used for treating hypogonadism that results from anemia and androgen deficiency (http://www.drugwiki.net/drugs/Testosterone_Enanthate).
Yes, there are steroidal health elements such as Dianabol (D-Bol), Parabolan, Anadrol, Finaject, etc. However, when it is about strength gain, increased muscle mass, and rapid weight gains, testosterone is unbeatable. Testosterone Enanthate is the European version of Testosterone Cypionate that is mainly available in the U.S. Testosterone Enanthate, just like many other trade names, is a long-acting depot steroid.
As per the metabolism and the initial hormone level in the body, it lasts for two to three weeks. And that is why theoretically, it is possible to take very long intervals between the injections. Even though Testosterone Enanthate is effective for multiple weeks; users usually take injections at least once a week in the field of powerlifting, bodybuilding, and weightlifting. Well, that definitely makes sense as Testosterone Enanthate has a plasma half-life time in the blood for a single week only.
The crucial benefit of Testosterone Tenantable is that is has a powerful androgenic effect. It helps the user build up a lot of strength and mass within a short time. However, fast and strong weight gain tends to come with distinct water retention. That means it causes fluid retention.
Side Effects of Testosterone Enanthate
The common side-effects of Testosterone Enanthate are commonly the androgenic effects and extensive water retention. Many athletes come across problems such as strong acne vulgaris with the administering of Testosterone Enanthate. Athletes, who administer high dosages of Testo, are often recognized easily with these features.
Surprisingly, in some athletes, these features only take place after they discontinue taking this compound. It basically implies a rebound effect. However, in some severe cases, medicine Accutane can bring relief. Treating gynecomastia needs the intake of an anti-estrogen. At the beginning of the intake sexual overstimulation along with frequent erections, is quite normal.
Along with virilization, testosterone can also accelerate the growth and maturation of bone. The other potential side effects are testicular weakening, poor spermatogenesis, increased aggressiveness, deep voice, accelerated hair loss, etc. Female users should normally avoid administering this as it could lead to unpleasant androgen-related side effects. They might have to deal with irreversible problems such as changes in voice, alopecia, and some reversible problems such as hirsutism and clitoral hypertrophy.
Now, again let’s move on to the main topic so you can better understand the difference between these two substances.
Testosterone Enanthate vs Testosterone Cypionate
As far as commercial usage is concerned, there are different types of the same steroidal elements accessible in the market. For example:
- Testosterone Cypionate
- Testosterone Enanthate
When you consume these, both of them come with noticeable effects. However, as far as the effects are concerned, the intensity of the effects tends to vary. Often people find it confusing to choose one of them. The experienced steroid users are aware of the fact that Enanthate and Cypionate are substitutable.
The choice is all up to you. Some people prefer taking one while others may switch on and off between these two substances. Several years back, the FDA restricted administering Cypionate and allowed it only for the use of hypogonadism and andropause.
If you talk in the generic terms, both testosterone Cypionate and testosterone Enanthate are administered interchangeably. But, there is a fine line of difference when it is about the effects of each compound.
The most common difference between Testosterone Enanthate and Testosterone Cypionate is that the last one lasts for a longer time. The usage of Testosterone Cypionate is limited within the US. That is why people often switch to testosterone Enanthate (https://cypionate.info/testosterone-enanthate-vs-testosterone-cypionate.html).
Check out the Differences in the chemical structure:
Along with the difference in the effect of these two substances, Testosterone Enanthate and Cypionate have a difference in their chemical structure too. Testosterone Enanthate has 7-carbons while Testosterone Cypionate has 8-carbons.
Cypionate takes a longer time to break down giving it a longer life. And that eventually makes it more effective than Enanthate.
Testosterone Cypionate and Testosterone Enanthate in brief:
- Testosterone Enanthate comprises a 7-carbon ester chain whereas Cypionate contains an 8-carbon ester chain.
- Testosterone, when consumed at a high dosage for a prolonged time tends to promote various side-effects such as gynecomastia, water retention, reduced fat breakdown, fat gain, lesser sex drive.
- Reckless dosages are likely to result in increased blood pressure.
- Administering testosterone can improve the quality of life. Contrarily, its uncontrolled usage can lead to many harmful side-effects too.
- Testosterone Enanthate doesn’t last long as Testosterone Cypionate.
- Testosterone Cypionate comes with a half-life of 12 days whereas, for Testosterone Enanthate, it is 10-11 days.
Testosterone Cypionate vs Testosterone Enanthate
Testosterone is a steroid hormone naturally produced in the human body. It is the main sex hormone and an anabolic steroid too. In men, it sustains the development of male reproductive tissues along with developing the secondary sexual traits such as muscle development, body hair growth, etc. Testosterone also helps in preventing osteoporosis and many other signs of aging.
Testosterone Cypionate and Enanthate are basically commercial steroids that are exceedingly popular in the bodybuilding community. These are used for increasing muscle mass. Testosterone Enanthate is a European steroid while Cypionate is an English steroid. Both promote the same effects and functions although some studies report that Cypionate leaves longer-lasting effects than Enanthate (http://www.differencebetween.net/science/difference-between-testosterone-cypionate-and-testosterone-enanthate/).
Testosterone Cypionate is limited within the U.S. And that is why Enanthate is known and used exceedingly by a large number of people as it is available even beyond the U.S. Testosterone Enanthate comes with a slightly faster release and comparatively shorter active life than that of Cypionate. IT depends on the carbon ester category. Enanthate comes with a 7-carbon ester chain while Cypionate comes with an 8-carbon ester chain.
The specific ester provides testosterone with its active life. The solubility of this product in oil and water depends on its ester category. The more carbons the ester category contains, the less soluble in water and more soluble in oil it becomes. Enanthate, with its 1-carbon atom and the 7-carbon ester, is lighter than Cypionate. And it contains more testosterone in every gram.
When people take Testosterone at a large dosage it can cause various side effects. It can transform into the female hormone estrogen by an aromatized enzyme. And this procedure is known as aromatization. To prevent this conversion, it is necessary to use a class of aromatized inhibitors. It helps in preventing the estrogenic effects like fat gain, gynecomastia, lack of libido, shrinkage of testicles, water retention, etc.
Water retention tends to weaken the blood vessels over a period of time since it boosts the blood pressure. With our increasing age, the testosterone level reduces. And it leads to loss of muscle mass and strength. Also, it promotes fat gain along with reducing the sex drive. It that case, testosterone replacement can be helpful. It will help in replacing the loss of testosterone especially among the middle to old-age people.
Testosterone supplements may help in delaying or preventing Alzheimer’s disease and other cognitive disorders among older users. It helps in protecting the nerves, in regenerating the motor units, while this also improves mood, memory, libido, appetite. Well, this is not the end. Along with improving the bone mass fighting osteoporosis, it lowers the chance of strokes or heart attacks too.
Thus, you can see that testosterone replacement helps in enhancing the quality of life. However, don’t forget that taking higher doses of steroidal health elements for a prolonged time can promote various side effects. Testosterone is the base of anabolic/androgenic steroid cycles as it is versatile. Various tests are available that help in cutting and bulking.
Now, when it comes to comparing these two testosterones as per there price, Enanthate is cheaper than Cypionate. Many of you might be wondering why. It is because testosterone with concentrated “T” or a high amount of “T” is cheaper compared to those which contain less “T.” This compound for beginners is cheap. And that is why it is the perfect choice for people who want to administer it to achieve their athletic or bodybuilding goals.
As far as the side effects are concerned, it is crucial to consult an expert before administering this product.
Testosterone Cypionate and Enanthate in brief
- Testosterone Cypionate and Enanthate are commercial steroids exceedingly popular in the bodybuilding community for increasing muscle mass.
- Testosterone Cypionate is an English steroid while Enanthate is a European steroid. However, both have the same effects and functions.
- Enanthate comprises a 7-carbon ester chain. On the other hand, Cypionate comes with an 8-carbon ester chain.
- Enanthate, with its 7-carbon ester and 1-carbon atom, is lighter than Cypionate that contains more testosterone per gram.
- Testosterone, when administered at high doses, can promote various side effects, such as fat gain, gynecomastia, reduction in fat breakdown, lack of libido, shrinkage if testicles, water retention, etc.
- Water retention weakens the blood vessels after a certain period of time since it increases blood pressure.
- With the increasing age, the testosterone level decreases. And that leads to loss of strength and muscle mass, fat gain, and lack of libido. That is why testosterone replacement is a helpful approach that helps in replacing the condition of testosterone loss, especially among the older people.
- Testosterone replacement will definitely improve the quality of life. However, you need to remember that taking high doses of these elements for a long time can lead to various side effects.
Testosterone Cypionate Or. Enanthate: Which One Is Better?
Men who are suffering from testosterone deficiency are ideal candidates for testosterone replacement treatment. And here, the biggest decision is to determine which therapy is to opt for. This can make you compare Testosterone Cypionate with Enanthate injections to decide which one is the better choice.
Before you make a decision, it is always advisable to consult an experienced hormone replacement specialist. If you think it will be okay talking to some local guys in your gym, you will be making a mistake. Remember one thing, what works for this guy may not be a suitable choice for that guy (https://www.hgha.com/blog/testosterone/testosterone-cypionate-vs-enanthate/).
There are some crucial facts to consider about both Testosterone Cypionate and Testosterone Enanthate. And we are going to be discussing some of those crucial factors here.
The prime difference between Testosterone Cypionate and Enanthate is the way they are generated:
- Testosterone Enanthate is suspended in sesame oil
- Testosterone Cypionate is suspended in cottonseed oil
Both of these injectable testosterones come with a sustained release time of 2 to 3 weeks. And that will vary from one man to the other depending on how his body uses and adapts the testosterone. One considerable difference is that testosterone Enanthate releases faster into the bloodstream. And that means it has a shorter half-life than testosterone Cypionate.
A half-life stands for the time a medication takes to release half of its strength. Keep scrolling down for learning more in this regard.
Comparison Chart Of Testosterone Cypionate And Testosterone Enanthate
Testosterone Cypionate and Testosterone Enanthate are two similar compounds. But, there are differences between these substances. Both of them are intramuscular, bio-identical, injectable substances. These are only legal to use when a licensed doctor prescribes this. Doctors prescribe this substance only to the patients who are suffering from testosterone deficiency.
Here is a comparison chart that will show you the difference between these two chemical compounds Testosterone Cypionate and Testosterone Enanthate. The experts in the field of endocrinology have gathered this information. And they are specialists who regularly prescribe the hormone.
Check out the following points:
- Suspended in sesame oil
- Slower release time
- Longer active life (lasts longer in the system)
- Has a half-life of 12 days
- Has less testosterone per milligram
- One carbon atom heavier
- Considered as an English steroid medication
- 8 carbon ester chain
- Usually more expensive
- Usually prescribed by doctors as a first choice.
- Suspended in cottonseed oil
- Faster release time
- Shorter active life (lasts shorter in the system)
- Has a half-life of 10.5 days
- Has more testosterone per milligram
- One carbon atom lighter
- Considered as a European steroid medication
- 7 carbon ester chain
- Usually less expensive
- Usually prescribed by doctors as a second choice.
Yes, there are some differences between the two medications. But those differences are not that notable. Both compounds offer similar advantages. Along with this, both compounds can promote the same negative side effects in case an allergic reaction takes place or if the users do not use the injections properly.
You can decide that the testosterone injectable medication is the best for you only after you go through thorough testing. Through this procedure, the doctors in charge can evaluate your medical condition and data. You can then determine which testosterone compound will bring you the most advantageous results.
Advantages and drawbacks of Testosterone Cypionate
As long as we are on the topic of half-lives, comparing testosterone Cypionate and Enanthate leads us to the fact that testosterone Cypionate comes with a half-life of 10 to 12 days. That is why it is such a popular option for so many users. That means you will have to take less frequent injections. Also, you will have to spend less money since you won’t have to purchase much.
The comparison between Testosterone Cypionate and Enanthate often leads to the first option since it is slower releasing than the other option. Testosterone Cypionate serves a more even release into the bloodstream but not a rapid jolt that often comes from Enanthate. This helps the users to avoid the high and low cycling that tend to affect mood, energy, and libido.
The testosterone Cypionate brands that are most extensively prescribed are Watson and Depo-Testosterone.
In brief, the pros and cons of Testosterone Cypionate (Depending on personal preference):
- Longer half-life
- Fewer injections
- Suspension in cottonseed oil
- Slower release into the bloodstream
Advantage and disadvantages of Testosterone Enanthate
As long as we are into the testosterone Enanthate vs. Cypionate debate, you have already come to know that the half-life of Testosterone Enanthate is 8 – 10 days. And that is a shorter period than that of testosterone Cypionate.
It means that users should administer the injections more frequently – maybe every 8 to 12 days. Well, the frequency of the injections will depend on the user and how the user reacts to the treatment.
A positive aspect for some male users is that in the first place, the release of testosterone into the bloodstream happens at a quicker pace when you compare Testosterone Enanthate with testosterone Cypionate. Sometimes, it can bring a speedier energy boost after you take the injection. Contrarily, the decline can also occur faster. And that is not a positive sign for some male users who have opted for this treatment.
Remember that each user will respond to the substance in a unique way. And you should discuss all forms of testosterone replacement therapy with a hormone specialist first. Watson and Delatestryl are the most recognizable brand names for testosterone Enanthate.
The pros and cons of testosterone Enanthate in brief:
- Shorter half-life
- More frequent injections
- Suspended in sesame oil
- Releases quicker into the bloodstream, and leaves sooner
Picking one between testosterone Cypionate and. Enanthate is a personal choice. And you should never start administering one without proper guidance. Diagnosing Low T needs blood analysis and physical examination as well.
Testosterone Cypionate or Testosterone Enanthate – Which one is to choose
Well, this is a fair question since these two compounds are similar. And just as many people report, both are slow-acting testosterone esters. They have the release time between 10-14 days. Also, they are interchangeable.
Yes, there is a little difference between these two compounds. Some bodybuilders report that Cypionate offers a little more “kick” than Enanthate. Well, this might contradict some of the data given below. Along with this, it produces a little higher level of fluid retention than Enanthate (https://genderoutlaw.wordpress.com/2008/12/17/testosterone-cypionate-enanthate/).
Difference between Cypionate and Enanthate?
- Enanthate is made extensively worldwide. On the other hand, Cypionate is not a common steroidal health element outside the USA. Therefore, Cypionate is likely to be more common in other States.
- Cypionate is suspended in cottonseed oil while Enanthate is suspended in sesame oil.
- Cypionate has an 8-carbon ester chain while Enanthate has a 7-carbon ester chain. For having more carbons in the ester group, it becomes more soluble in oil and the less soluble in water. That is why Cypionate comes with a comparatively longer active life and slower release.
- For being one atom lighter, Enanthate contains more testosterone per mg. The difference is not so significant although, several milligrams amount of steroid more perhaps.
Well, the price is another difference that leads people to choose Enanthate over Cypionate. Cypionate tends to be a little more expensive. Some people report paying $35.99 CAD for 10 ml of 100 mg/ml of Testosterone Cypionate. On the other hand, some report paying $60.76 CAD for 10 ml of 200 mg/ml of Testosterone Enanthate.
Well, that is just over $10 CAD cheaper, although it is not clear if that is because it’s Enanthate or because it’s the higher concentration (You already know that higher concentration T is less expensive usually.) To speak practically, Enanthate and Cypionate are identical virtually.
Just as having the quality testosterone compound is important, consulting the right expert is crucial too. If you have already consulted an expert and he/she is not able or willing enough to solve your queries, it is time you go for consulting someone else. They will get you a comprehensive solution in this regard – including dosage, diet, lifestyle, exercise, safety measures, etc.