Masteron 101 – Everything That You Need To Know


Masteron is, to be honest, my favorite Anabolic/Androgenic Steroid (AAS). For many years, this compound was unavailable to the average athlete; it was frequently counterfeited, often very expensive, and seldom available on the black market. The most common form of this product, as manufactured by major pharmaceutical houses, is 50mg/ml ampules with either 1-2mls per amp (or vial). These products used to be the only game in town, and since this drug was a particularly sought-after compound for bodybuilding contest preparation, it’s price made it prohibitive for all but the highest level bodybuilders.

Masteron is a derivative of DHT (as you can tell from its chemical name: 2a-methyl-dihydrotestosterone propionate). However, what they fail to say to you is that DHT and its derivatives are commonly used in the treatment of certain forms of breast cancer (see the etymology here: MASTectomy, gynocoMASTia, MASTeron, get it?). Masteron is not for weight gain (as is common with most steroids), so this makes it a unique steroid from that perspective.


Unfortunately, much of the information on Masteron available in medical journals don’t focus on weight or strength gain or even fat loss, for those reasons. Most reports on Masteron focuses on its use in treating certain forms of breast cancer, and it does this reasonably well. To give you an idea, Masteron + Tamoxifen fared better than Chemotherapy for immediate objective responses from patients. So? What does this tell us? Well, this makes it a fascinating drug for a lot of reasons.

It won’t aromatize at all, nor will it have progesterone side-effects. Remember, Nolvadex (and most ancillaries) are to reduce estrogen for breast cancer patients, so a drug used to treat breast cancer obviously wouldn’t convert to estrogen. Furthermore, Masteron may interact with the aromatase enzymes to inhibit the aromatization of other steroids into estrogen. Additionally, it may interact with estrogen (as a “blocker” of sorts) at the receptor site. That is how it helps to combat breast cancer, obviously, but this could also be part of the reason that Masteron is considered a “cutting” or “Pre-contest” drug. Masteron may be beneficial for combating estrogenic/progesterone side effects yes, you read that right, if you include Masteron in your cycle, you may not need other “ancillary” drugs like Arimidex or Letrozole).

Drostanolone Enanthate

Hence, much like Proviron, you can use Masteron as an anti-side-effect-drug. (Remember, most ancillary drugs we use to combat estrogenic sides, like Nolvadex, letrozole, and Arimidex to fight breast cancer). Along a similar line, being a DHT (DiHydroTestosterone) derivative, it’s got a beneficial ability to add muscle hardness to an already lean physique. Remember, Masteron has a deceivingly low anabolic/androgenic ratio. Still, since DHT is 5x as androgenic as testosterone and has a 3-4x higher affinity to receptor sites, Masteron provides a lot of “bang for the Buck” when examined on an Mg for Mg basis.

Masteron – Stronger Than It Seems

In my experience, as well as many others, Masteron is a more potent androgen than it appears on paper, and this could cause increased aggression. As we know, higher androgens also produce that “hard” look prized by competitive BB’ers, and as we all know, androgens also promote lipolysis (fat loss). The effects of Masteron, in that way, are consistent with the documented effects of (somewhat heavier) androgens. It decreases lipoprotein lipase and upregulates -adrenergic receptors on adipocytes. Therefore, it would inhibit the accumulation of lipid (fat) and enhance the efflux of lipid from these cells in response to catecholamines.

So, as I said previously, don’t let Masteron’s deceptively low Anabolic to Androgenic ratio fool you. It helps eliminate fat as well (if not better) than much more highly scored androgens, in part due to its being a derivative of DHT. This reduction in fat and rise in aggression (making workouts more effective) could be beneficial for people competing in a sport or who are on a reduced-calorie diet. Sounds pretty good, right? Unfortunately, being a DHT derivative means that it can have certain undesirable sides as well (acne, hair loss, prostate enlargement, etc. & you may want to consider using Finasteride with this drug).

Water retention (and increased danger of high Blood Pressure) with this compound is virtually nil, and liver toxicity is not much of an issue either. You can take heaps of this stuff. The maximum therapeutic dose is pretty high: 167mgs/kg-bodyweight/day. So that’s 167mgs per day, every day of the week, for a 220lb person, and that’s not considered excessive by the FDA, who hasn’t been very traditionally liberal on dosing protocols. So clearly, up to that dose is very safe for almost anyone. DHT has a bad reputation for causing prostate hypertrophy, acne, and hair loss, but most people I’ve talked to find that reputation to be mostly undeserved, at least in the case of Masteron.

Remember that year that the Chinese National Swimming Team (women’s) were kicking everyone’s ass? Or the year that the German National Swimming Team (again, I’m talking about women) were taking all those Gold medals? They were all using a form of DHT or a derivative, possibly Masteron. The German Women had very deep voices, which leads me to believe that Masteron’s virilizing effects on women could be terrible. Hence, I feel Masteron is an excellent drug for any athlete, but possibly not for women (at least not at high doses, perhaps 50mgs/E3D is appropriate). Sorry girls, you can have a go with this drug, but keep the doses low.


Stacking Masteron? Well, I’d say that your best bet is with testosterone, of course. However, due to Masteron’s reasonable binding to the Androgen Receptors and its high androgenic properties, almost any cutting drug (Tren, Anavar, etc.) could be included in a cycle with it for an efficient stack. I have a feeling that due to Stanozolol’s (Winstrol) non-AR mediated effects, and its ability to reduce SHBG, a stack including both of these drugs would be very synergistic. However, don’t forget the testosterone, as Masteron will reduce your natural testosterone levels. Since you are going to have to inject Masteron every other day at least, you might as well stack it with Testosterone Propionate, and possibly injectable Winstrol. And maybe Tren Acetate, if you’re inclined to use a lot of compounds in the same cycle & and I know I am). Eq is another popular choice to stack with Masteron.

I’d say that the optimum effects of this stuff are with 4-500mgs/week (based on conversations I’ve had with people who have used Masteron, as well as my results). I happen to have a friend who has gone up to 600mgs/week with Masteron and didn’t feel that it provided significantly better results than 400-500mgs per week. I think, for maximum cost-effectiveness, 400mgs per week is ideal. It’s also important to remember to spread those shots out on an every other day basis, as the Masteron I’m talking about here is the Propionate version, and as such, requires more frequent dosing.

There is another form of Masteron out there: Drostanolone (base), yeah, that’s right, Masteron without an ester. It’s called Dromostan, and the Xelox Company makes it. I’ve never tried this version, and don’t know anyone who has, but I suspect that it would be a very potent product, but you would need to inject every day.

Masteron profile

(Drostanolone Propionate) [17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one propionate] Molecular Weight: 360.5356 Formula: C23H36O3 Melting Point:N/A Manufacturer:Syntex, Various Underground Labs Effective Dose (men):350mgs/week (*100mgs Every other day) to 500mgs/week Effective Dose (women): 25-50mgs Every other Day to Every Third Day Active Life:2-3 days Detection time: 3 weeks Anabolic/Androgenic Ratio:62:25


Masteron Enanthate Profile

(Drostanolone Enanthate) [17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one Enanthate] Molecular Weight: 360.5356 Formula: C23H36O2 Melting Point:N/A Manufacturer: Dpharm, others Effective Dose (men):400-600mgs/week Effective Dose (women): 100mgs/week Active Life: 8 days Detection time: up to 3 months Anabolic/Androgenic Ratio: 62:25

While the Masteron steroid is most commonly found in the Propionate form, Masteron-Enanthate is also available. Still, most will find it to be a little rarer than the original form. As we will see, there is very little difference between the two forms, in-fact the benefits are identical with each, and while this is common in the steroid world, it’s even more so here. For example, Nandrolone anabolic steroids most commonly come in Decanoate and Phenylpropionate form. And while the mode of action is very similar in both, there are some slight significant differences in the two compounds; this is not the same, to such a large degree, regarding Drostanolone steroids. Nevertheless, there is a difference but it only revolves around the ester and does not provide a significant advantage. Furthermore, as Masteron was to fight breast cancer, you will find Masteron-Enanthate versions to be a performance-based medication only and largely only on the black market.

Masteron-Enanthate 101

Masteron, officially known as Drostanolone is a Dihydrotestosterone (DHT) derived anabolic steroid most commonly found in a Propionate version, but it is the Enanthate version we are concerned with here. Structurally Masteron-Enanthate is almost identical to Masteron-Propionate; both forms are DHT derived Drostanolone; both exist by the added 2a-methyl grouping with the only difference being in the attached ester.

While both Masteron forms are very similar, Masteron itself holds a bit of a unique place in the anabolic steroid world. It is one of the few initially designed for medical purpose steroids that were not to treat anemia or muscle wasting diseases such as aids or cancer. Masteron exists based on the fight against breast cancer, and once we understand the hormone, this will make perfect sense.

The number one enemy of breast cancer patients is estrogen. For this reason, many SERM’s and AI’s are often given to breast cancer patients as they can reduce and block estrogen buildup. Masteron also possesses this trait; as a DHT based anabolic steroid, you will find this steroid does not aromatize, and in-fact appears to have a decent anti-aromatase effect. At one point in time, the combination of Masteron and Tamoxifen-Citrate was rather commonplace in breast cancer patients as Tamoxifen will actively block estrogen from binding at the breast receptors, and Masteron actively reduces the amount in the body.

However, such practice has mostly fallen out of popularity as most attending physicians will prescribe aromatase inhibitors “AI’s” more frequently as they are far more powerful and can reduce estrogen dramatically. For the performance enhancer, this anti-aromatase effect is a particular interest as it will affect the other steroids in the system that do aromatize positively. As this is a strong attribute of the Masteron-Enanthate steroid, by far, it is also the most significant in many ways.

Masteron is an anabolic steroid with both low anabolic and androgenic properties. While mildly androgenic, it does, however, possess more definite androgenic traits than would be expected. As we discuss the benefits of Masteron-Enanthate, you’ll be able to easily see how the androgenic traits coupled with the anti-aromatase nature might benefit the performance enhancer. When examining Masteron-Enanthate, we find it is one of the few exceptions to the rules of primary and secondary roles. For example, testosterone is a solid hormone that will serve any cycle for any purpose. Many steroids, such as Anadrol, while primarily a bulking steroid carries with them secondary characteristics that make them useful for cutting; Masteron does not possess this trait.

The Benefits of Masteron-Enanthate

The benefits of Masteron-Enanthate can mostly be summed up in three words, lean and hard. For the performance enhancer and outside of a breast cancer patient, it will only be performance enhancers of a bodybuilding nature who supplement with Masteron in the first place as it is an excellent physique transforming steroid. Still, it is not a miracle in a bottle. Even though it has a rather mildly low androgenic rating, the story it tells is somewhat different as it will harden one up quite decently.

Furthermore, as is by its nature, Masteron-Enanthate effects overall metabolic activity by directly stimulating lipolysis; no, it is not the only steroid that presents such benefits, nor is it the strongest one, but these are primarily the traits. As stated, this is not a miracle steroid; a good steroid absolutely, but it holds nowhere near the power of say Trenbolone that also significantly promotes hardness and lipolysis, among many other traits.

However, Masteron-Enanthate is far milder than Trenbolone, but before you get too excited, you need to understand an important fact. If you’re sitting there at 20% body-fat Masteron-Enanthate is not going to do a lot for you; to benefit from this steroid, you already need to be relatively lean, as the effects won’t be all that noticeable unless you are. Yes, it may indeed help you lose a little fat if you are at a high percentage of body-fat, but there are other things you can use, and other things you can do that will be far more beneficial and far more worth your time and money.

To truly benefit from the Masteron-Enanthate hormone, we need to be below 8%, and most will find below 6% to be even better. If we are this lean when we begin using the steroid, the hardening effect brought on by both its androgenic nature and ability to have an anti-aromatase effect will be pretty close to amazing. Further, for the competitive bodybuilder looking to drop that last little bit of fat, this hormone can be even more useful as Masteron may be the final ingredient missing to do just that.

The Side-Effects of Masteron-Propionate

As Masteron-Enanthate is a member of the anabolic androgenic steroid family, it will carry with it a potential for adverse side-effects. However, always remember potential does not mean guaranteed, it merely means there is a chance, and the probability here is rather low.

How low? Many of the over the counter medications you buy in your local drug store have more severe potential side-effects than Masteron-Enanthate. While this is common regarding most anabolic androgenic steroids, in general, it is even more applicable to Masteron.

The most common side-effects of Masteron-Enanthate are going to be two of the most common DHT related side-effects, and they include acne and hair loss, and in all honesty, that’s about it. Masteron-Enanthate does not aromatize, and side-effects such as Gynecomastia and water retention are of no concern; it does not appear to have a substantial impact on your lipid profiles and is all-in-all a very mild steroid.

However, you should note that, while Masteron does appear to be a very mild and side-effect friendly anabolic steroid, it is one of the few anabolic steroids that is lacking in information regarding side-effects.

As for hair-loss, if you lose any hair while using Masteron-Enanthate, you were going to go bald anyway; Masteron just sped it up. If you’re not genetically predisposed to baldness, Masteron will not affect your hairline. In a sense, we can say the same thing of acne; your sensitivity will determine the extent, if any; most will have no problem at all and won’t see a single zit.

However, if you are sensitive to acne in any degree, you may have some bumps pop up; keeping your skin extra clean can help you with this and up your odds in terms of protecting your skin.

All-in-all we can safely say Masteron-Enanthate is one of the safest anabolic steroids of all.

Masteron-Enanthate Purpose

As Masteron-Enanthate only serves the purpose of leaning out and hardening up, you will generally only see the steroid used in the competitive bodybuilding world and by those of a performance-enhancing nature who do so only to look and feel better. You will not find a lot of Masteron in the athletic performance world; there’s not a lot of purpose for the football or baseball player or any other on the field athlete. Sure, some of them may dabble with Masteron, but most will choose other anabolics that serve their purpose.

Ronnie & Arnold

However, for the bodybuilder, this anabolic steroid can be the difference between a first and second place in a show; after all, while there are many factors to being a successful bodybuilder on stage hardness and ultimate leanness are two of the primary concerns.

Ultimately this is one of the few anabolic androgenic steroids we can almost aptly label a pure bodybuilding steroid.

Masteron-Propionate Cycles & Doses

While Masteron-Propionate is very fast-acting and short-lived in duration, we can not say the same about the long ester Masteron-Enanthate form. Due to this fact, one will find the Enanthate version may be injected far less than its Propionate brother.

Masteron-Propionate must necessarily be injected every other day, but the Enanthate form is well-suited at a mere two injections per week. That is perhaps the only real distinct advantage of the Enanthate form over the Propionate form; one can inject far less frequently; however, it may not be as much of an advantage as you think.

Masteron is, for all intense purposes, a steroid that you will generally use while you are cutting. Especially at the end of a contest bodybuilding cycle, most individuals will be using other short ester based anabolics and injecting on every day to every other day basis, to begin with. If this is the case, you’re better off only going with Masteron-Propionate as it is generally a purer substance; Masteron-Enanthate in itself is not the problem but many of the labs who make it seem to have a hard time with it.

For the standard bodybuilding dose, most will run approximately 300-400mg per week of the compound with 600mg per week generally being considered a high-end dose and about as high as you’ll ever need to go, and most will never need to go this high.

You could run less than 300mg, but 200mg per week would be the minimum to see any results, and in most people, 200mg won’t provide that much of a bump. Most bodybuilders and gym rats will find Masteron-Enanthate to be a welcomed addition to a stack when dieting and, in most cases, the final 6-8 weeks of the cycle.


Masteron is one of the best AAS products that there are. They are very safe, even up to the maximum effective doses. However, as with all steroids, you still need to take some precautions. Ensure that you have blood tests done regularly, and check with your doctor to see if you have any underlying conditions that Masteron could effect.


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